As proposed by the chiropractor Dr Michale Flanagan in his book “The Downside of Upright Posture”:
It would appear that in the presence of an atlas malalignment, drainage of CSF and venous blood from the brain may be compromised, leading to the accumulation of toxic metabolites like haemosiderin.
Chronic venous ulcers in the ankles of the elderly are another example of this phenomenon.
Until very recently, Dr Flanagan’s suspicion has been unsupported by evidence.
Now we have evidence, and until that is refuted, this hypothesis stands as having both physiological plausibility and scientific evidence: